Pioglitazone is a class II BCS drug having poor water solubility, slow dissolution rate and hence it may have negative impact on its bioavailability. Sub therapeutic plasma drug level of this drug is observed due to poor water solubility and thus it may lead to therapeutic failure. In order to improve its solubility and thus dissolution rate cyclodextrin complexation technique was followed. Binary system of pioglitazone with β-CD and HP β-CD were prepared separately by kneading method and evaluated for various parameters. The IR spectra confirmed the formation of a complex in between drug and cyclodextrin. The complexes prepared with the molar ratio 1:2 (drug: complexing agent) offered better dissolution rare. Mouth dissolving tablets were prepared with such complexes by employing wet granulation technique .The tablets were subjected to various quality control tests .The tablets containing the superdisintegrating agent crosspovidone and Pioglitazone-HPβCD complex showed immediate disintegration and fast rate of drug release.
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